Cardiovascular phenotype characterization in mice by high resolution magnetic resonance imaging |
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Authors: | Frank Wiesmann Jan Ruff Charlotte Dienesch Andrea Leupold Eberhard Rommel Axel Haase Stefan Neubauer |
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Affiliation: | 1. Medizinísche Universit?tsklinik Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Germany 2. Physikalisches Institut, Universit?t Würzburg, Germany 3. Department of Cardiovascular Medicine, Oxford University, Oxford, UK
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Abstract: | 9. Conclusion Due to its high temporal and spatial resolution, magnetic resonance imaging meets the requirements for accurate and robust
in vivo visualization of the murine cardiovascular system. As an intrinsically three-dimensional imaging technique, it allows
for quantification of LV volumes without relying on geometric models. Therefore, MRI is uniquely suited for the investigation
of morphologic and functional changes in models of heart failure.
The potential application of MRI in the mouse comprises visualization of cardiovascular anatomy and pathology in newborn and
adult mice, detection of LV geometric and functional changes both acutely and chronically, visualization of cardiac microstructures
such as cardiac valves and coronary arteries, and characterization and quantification of arteriosclerotic plaques in major
murine arteries. Furthermore, MR spectroscopy applied to the mouse heart can give important information on in vivo myocardial
metabolism. Thus, we feel confident that high resolution MRI may substantially contribute to the understanding of the basic
mechanisms of a variety of cardiovascular diseases. |
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