CDC15, an essential cell cycle gene in Saccharomyces cerevisiae, encodes a protein kinase domain |
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Authors: | B Schweitzer P Philippsen |
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Affiliation: | Institut für Mikro- und Molekularbiologie der Universit?t Giessen, F.R.G. |
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Abstract: | The cell division cycle gene CDC15 is essential for the late nuclear division in the yeast Saccharomyces cerevisiae. The amino acid sequence of the 974 amino acids/110 kDa CDC15 gene product, as deduced from the nucleotide sequence, includes an aminoterminal protein kinase domain which contains a primary sequence mosaic showing patterns specific for protein serine/threonine kinases besides those for protein tyrosine kinases. Many protein kinases non-essential for growth are known. CDC15 represents an essential protein kinase like CDC7 and CDC28. A carboxyterminal deletion of 32 amino acids renders the protein inactive. |
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Keywords: | cell division cycle Saccharomyces cerevisiae CDC 15 protein kinase |
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