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Particle Morphology of Amorphous Aluminum Hydroxycarbonate and Its Effect on Tablet Production |
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| Authors: | Jue-Chen Liu Joseph R. Feldkamp Joe L. White Stanley L. Hem Nobuo Otsuka Dorothy F. Conroy Chandrashekhar M. Pendharkar Kenneth M. Feld Richard J. Harwood Wayne M. Grim |
| Affiliation: | a Department of Industrial and Physical Pharmacy, Purdue University West Lafayette, INb Department of Agronomy, Purdue University West Lafayette, INc School of Materials Engineering Purdue University West Lafayette, INd Rorer Group Inc. Fort Washington, PAe Squibb Institute for Medical Research New Brunswick, NJ |
| Abstract: | The particle morphology of amorphous aluminum hydroxycarbonate was studied by disaggregation induced by phosphate adsorption and direct observation by high resolution transmission electron microscopy. The primary particles are sheet-like and have equivalent diameters of 55A or less. The primary particles are believed to correspond to planar polymers comprised of six-membered rings of aluminum ions joined by double hydroxide bridges. Secondary particles form by attractive interaction of primary particles. The size of the primary particles affects the porosity of the secondary particles. The granulating and tableting properties of two spray dried amorphous aluminum hydroxycarbonates were shown to be related to the size of the primary particles and the porosity of the secondary particles. |
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