Association analyses of single nucleotide polymorphisms in the LEP and SCD1 genes on the fatty acid profile of muscle fat in Simmental bulls |
| |
Authors: | Orrù L Cifuni G F Piasentier E Corazzin M Bovolenta S Moioli B |
| |
Affiliation: | a Consiglio per la Ricerca e la Sperimentazione in Agricoltura, CRA-GPG, via San Protaso 302, 29017 Fiorenzuola d'Arda, Italy;b Consiglio per la Ricerca e la Sperimentazione in Agricoltura, CRA-PCM, Monterotondo, Italy;c Department of Animal Science, University of Udine, via Sondrio 2A, 33100 Udine, Italy |
| |
Abstract: | The aim was to investigate the effect of the genetic polymorphisms of leptin (LEP) and stearoyl-CoA desaturase (SCD1) genes on the fatty acid (FA) composition of the muscle of 103 Simmental bulls. Ten single nucleotide polymorphisms (SNP) were detected in exons 2 and 3 of the LEP gene, two of them encoding non-synonymous mutations. Allelic substitution effects of all the SNP on 28 single fatty acids, monounsaturated (MUFA) and polyunsaturated (PUFA) and desaturation indexes were estimated. Both the SCD1 SNP, as well as three SNP of the leptin gene, affected, to different extents, the desaturation of FA into MUFA. Because it was previously proposed that leptin's metabolic action involves down-regulation of SCD1, it is possible that, beyond the mere additive effect of SCD1 gene on FA desaturation, the non-synonymous mutations in the leptin gene also contribute to the variability of FA composition in muscle fat. |
| |
Keywords: | Fatty acid composition Polymorphism Stearoyl-CoA desaturase (SCD1) Leptin |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|