Synthesis and characterization of photo-crosslinkable hydrogel membranes based on modified chitosan |
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Authors: | M. Monier Y. Wei A.A. Sarhan |
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Affiliation: | a Chemistry Department, College of Art and Science, Drexel University, Philadelphia, PA 19104, USA b Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt |
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Abstract: | In order to develop a non toxic and biocompatible hydrogel system with potential ability in biotechnology, modified photo-crosslinkable hydrogel membranes based on chitosan were prepared. Using an EDC/NHS conjugation method, chitosan was chemically modified to incorporate a photosensitive α-cyano-4-hydroxycinnamic acid moiety with various degrees of substitutions. Fourier transform infrared spectra (FTIR), proton nuclear magnetic resonance (1H NMR) and ultraviolet-visible light spectra (UV-vis) were used for structural characterization of modified chitosan, The obtained membranes were crosslinked by irradiation in the ultraviolet region, where the photosensitive monomers showed maximum sensitivity. The prepared photo-crosslinked hydrogel membranes were investigated by thermal gravimetric analysis (TGA) and wide angle X-ray diffraction (WAXD). The swelling behaviors were investigated in terms of pH, time of swelling, and degree of substitution. Also, mechanical properties of the different photo-crosslinked hydrogel membranes were studied in both dry and wet conditions. |
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Keywords: | Chitosan α-Cyano-4-hydroxycinnamic acid Photo-crosslinkable |
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