ICR小鼠与BalB/c小鼠在构建正常小鼠模型中的比较

小鼠模型广泛应用于食品科学、毒理学及相关学科。为提供ICR小鼠和BalB／c的背景，本研究考察了10项免疫指标治疗。选用ICR小鼠、BalB/c小鼠各60只，按《保健食品功能学评价程序和检验方法》进行试验。在迟发型变态反应(DTH)、半数溶血值、巨噬细胞鸡红细胞吞噬率、NK细胞活性4项指标中，BalB／c小鼠显优于ICR小鼠，揭示在这4项实验中BalB／c小鼠应为首选。在脾脏体重比值、ConA刺激的小鼠淋巴细胞转化、单核—巨噬细胞碳廓清能力、巨噬细胞鸡红细胞吞噬指数4项指标中，两种小鼠差异没有显性，因此在这4项实验中ICR小鼠可以替代BalB/c小鼠。另外，在胸腺体重比值、小鼠的抗体生成细胞数两项指标中，ICR小鼠的表现优于BalB/c小鼠，其机理还不明了，有待进一步研究。

Comparison between ICR mice and BalB/c mice for constructing normal mouse model

Mouse model is widely used in food science,toxicology and other related areas.In order to provide background data on ICR and BalB/c mice,ten immunological parameters were tested on 60 ICR mice and 60 BalB/c mice according to national standard method for evalution on health food.The results showed significant difference in delayed type hypersensitivity (DTH),antibody integral of sero hemolysin,phagocytosis percentage of murine peritoneal macrophage and natural killer cell activity.It suggests that BalB/c mice is better in researches using the above four parameters.In spleen-body weight ratio,transfer ability of lymphocyte by ConA stimulation,clearance index of charcoal particles and phagocytosis index,no significant difference was shown,suggesting that ICR mice can be appropriate alternative for BalB/c mice in such tests.In addition,ICR mice showed higher sensitivity in thymus-body weight ratio and PFC.The underlying mechanism of such phenomena is still unknown,requiring further research.