Neurotoxicodynamics of the interaction between ciprofloxacin and foscarnet in mice |
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| Authors: | H Matsuo M Ryu A Nagata T Uchida JI Kawakami K Yamamoto T Iga Y Sawada |
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| Affiliation: | Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan. |
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| Abstract: | The potential for convulsions induced by the coadministration of ciprofloxacin (CPFX) and foscarnet (PFA) may be due not to a change in the distribution of CPFX to the brain but to a potential CPFX-induced inhibition of gamma-aminobutyric acid (GABA)-GABA(A) receptor binding in the presence of PFA. |
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