Synthesis and characterization of collagen/hydroxyapatite: magnetite composite material for bone cancer treatment |
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Authors: | Ecaterina Andronescu Maria Ficai Georgeta Voicu Denisa Ficai Maria Maganu Anton Ficai |
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Affiliation: | (1) Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania;(2) Center of Organic Chemistry “Costin D. Nenitescu”, Romanian Academy, 202B Splaiul Independentei, 050461 Bucharest, Romania; |
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Abstract: | Our purpose was obtaining and characterizing a complex composite system with multifunctional role: bone graft material and hyperthermia generator necessary for bone cancer therapy. The designed system was a magnetite enriched collagen/hydroxyapatite composite material, obtained by a co-precipitation method. Due to the applied electromagnetic field the magnetite will induce hyperthermia and cause tumoral cell apoptosis. The complex bone graft system was characterised by XRD, FTIR and SEM, while the hyperthermia was quantify by measuring the temperature increase due to the applied alternative electromagnetical field. |
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