Study on structural optimum design of implantable drug delivery micro-system |
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| Affiliation: | 1. Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX;2. Department of Surgery, University of Texas Medical Branch, Galveston, TX;3. Shriners Hospitals for Children, Galveston, TX;4. Sulpizio Cardiovascular Center, University of California, San Diego, CA;5. University of Arkansas for Medical Sciences, Little Rock, AR |
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| Abstract: | In this paper, design, modeling, and simulation of a new type of controlled drug delivery system based on biodegradable polymers is report. The system consists of arrays of micro-chambers for drug storage to achieve linear release. The micro-chambers were fabricated with biodegradable polymer using the UV-LIGA technology and the controlled release process is the combined results of design of the micro-chambers and the biodegradable characteristics of the polymer. This type of drug delivery system has some unique advantages in controlled long-term drug delivery, such as improved efficiency, reduced side effect, on-spot delivery, and convenient therapy. Mathematical model has been developed for two kind of biodegradable polymer micro-system respectively, and numerical simulations were conducted to analyze the biodegradation and the controlled release process. The mathematical model can be used to optimize the structural design for controlled-release system with the desired release characteristics. |
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