CuI as reusable catalyst for the Biginelli reaction |
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| Affiliation: | 1. School of Pharmaceutical Science, Jiangnan University, Wuxi, 214122, China;2. Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, 311121, China;1. Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Mysuru 570 015, Constituent College of JSS Academy of Higher Education & Research, Mysuru 570 015. India;2. Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty 643 001, Nilgiris, Tamil Nadu, India;3. NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Nitte (Deemed to be University), Mangalore 575018, Karnataka, India;4. Department of Pharmaceutical Chemistry, Acharya & BM Reddy College of Pharmacy, Bengaluru 560 107, India;5. Bioanalytical Division, Biocon Pvt. Ltd, Bengaluru 560 100, India;6. Bioanalytical Division, mAbxience Insud Pharma, Madrid 28050, Spain;1. Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG 31270-901, Brazil;2. Departamento de Botânica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG 31270-901, Brazil |
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| Abstract: | An improved protocol for the Biginelli reaction using CuI as a reusable catalyst is described. The synthesis of 3,4-dihydropyrimidin-2(1H)-ones was achieved in acetonitrile, water and under solvent-free condition. After separation of product from the reaction mixture, the mother liquor (acetonitrile or water) containing the catalyst was reused two times without any loss of activity. |
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