中空铋材料的制备及药物体外释放的研究

为了考察钨酸铋中空纳米材料负载抗癌药物盐酸阿霉素的体外释放特性，利用硝酸铋、钨酸钠、聚乙烯吡咯烷酮，在一定配比的混合溶剂中，水热法制备中空铋材料，并结合X射线衍射、热重分析、扫描电镜、透射电镜和紫外分光光度计对其结构和形态以及对药物负载释放作用进行了研究。在改进原有制备方法基础上，制备的中空铋材料外观尺寸40~50 nm，中空结构尺寸为20~30 nm，并具有良好的载药热稳定性。同时，在pH7.5和pH5.0环境下，钨酸铋中空纳米颗粒负载盐酸阿霉素的释放率分别是14%和43%，显示出弱酸性条件下药物释放效果明显优于弱碱性环境条件。因此，这种中空铋纳米材料在负载抗癌药物盐酸阿霉素控释系统中具有一定的潜在应用前景。

Preparation of Hollow Bismuth Materials and Release of Loaded Drug in Vitro

To investigate the in vitro releasing properties of anticancer drug doxorubicin hydrochloride encapsulated in the bismuth tungstate hollow nanomaterial， bismuth nitrate， sodium tungstate and polyvinylpyrrolidone （PVP） were used to prepare the hollow material in a certain proportion of mixed solvent by hydrothermal method. Through X-ray diffractometry， thermogravimetric analysis， scanning electron microscopy， transmission electron microscopy and ultraviolet spectrophotometry， the structure and morphology of this hollow nanomaterial were confirmed and its effect on drug release was analyzed. The results showed that the releasing rates of doxorubicin hydrochloride encapsulated in the bismuth tungstate hollow nanoparticles are 14% and 43% at pH 7.5 and pH 5.0， respectively. Therefore， the drug releasing effect under acidic condition is significantly better than that under weak alkaline condition. This bismuth tungstate hollow bismuth material has a prospect of application in the controlled-releasing system of anticancer drug doxorubicin hydrochloride.