Development of an Artificial Lipid-Based Membrane Sensor with High Selectivity and Sensitivity to the Bitterness of Drugs and with High Correlation with Sensory Score |
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| Authors: | Yoshikazu Kobayashi Hikari Hamada Yasuhiro Yamaguchi Hidekazu Ikezaki Kiyoshi Toko |
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| Affiliation: | 1. Intelligent Sensor Technology, Inc., 5-1-1 Onna, Atsugi-shi, Kanagawa 243-0032, Japan;2. Information Science and Electrical Engineering, Kyushu University 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan |
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| Abstract: | This paper reports the development of membrane sensors based on an artificial lipid and plasticizers with high selectivity and sensitivity to drug bitterness by using bis(1-butylpentyl) adipate (BBPA), bis(2-ethylhexyl) sebacate (BEHS), phosphoric acid tris(2-ethylhexyl) ester (PTEH), and tributyl o-acetylcitrate (TBAC) as a plasticizer and phosphoric acid di-n-decyl ester (PADE) as an artificial lipid to optimize surface hydrophobicity of the sensors. In addition, a sensor with highly correlated bitterness sensory score was developed by blending BBPA and TBAC to detect the bitterness suppression effect of sucrose, and other bitter-masking materials. Therefore, this sensor can be used to evaluate the bitterness of various drug formulations with high accuracy. Copyright © 2009 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc. |
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| Keywords: | evaluation of drug bitterness artificial lipid-based membrane plasticizer hydrophobic interaction bitterness suppression effect bitter-masking material |
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