鼠神经生长因子治疗肺癌并发带状疱疹神经痛的临床观察

目的:观察鼠神经生长因子联合椎旁神经根阻滞治疗肺癌併发带状疱疹神经痛的临床疗效。方法:将40例具有典型带状疱疹神经痛表现的肺癌患者随机分为A组(实验组)和B组(对照组)各20例。治疗组给予鼠神经生长因子肌注1支每日一次+椎旁神经根阻滞每周2次;对照组给予椎旁神经阻滞每周2次。观察治疗后1周、2周疼痛指标及1月后的随访结果。结果:比较两组患者的疼痛指标及总体疗效,A组优于B组,有显著性意义P0.05。结论:鼠神经生长因子联合椎旁神经根治疗肺癌伴带状疱疹神经痛优于单纯椎旁神经阻滞治疗。

Observation of treatment of lung cancer associated herpes zoster neuralgia by mouse nerve growth factor

Objective：To observe the effect of mouse nerve growth factor on herpes zoster neuralgia in lung cancer patients. Methods：A total of 40 lung cancer patients with typical performance of herpes zoster neuralgia were randomly assigned to either experimental group （Group A） receiving mouse nerve growth factor and paravertebral block anesthesia, or control group （Group B） only receiving paravertebral block anesthesia. Visual ana-logue scale and curative effect were assessed at the day 7, 14days. Results of one-month follow-up were acquired by the phone call. Results：Group A got much better results than the group B in terms of curative effect （P〈0.05）. Conclusion：The therapy of mouse nerve growth factor associated with paravertebral block anesthesia can achieve more significant curative effect on herpes zoster neuralgia in lung cancer patients and is worth of spreading.