| 肝素化丝素／聚氨酯共混膜的制备及其缓释性能 |
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| 引用本文： | 许海叶,;杨红军,;王维慈,;欧阳晨曦,;徐卫林.肝素化丝素／聚氨酯共混膜的制备及其缓释性能[J].武汉纺织工学院学报,2008(7):1-5. |
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| 作者姓名： | 许海叶 ;杨红军 ;王维慈 ;欧阳晨曦 ;徐卫林 |
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| 作者单位： | [1]武汉科技学院新型纺织材料绿色加工及其功能化教育部重点实验室,湖北武汉430073; [2]东华大学纺织学院,上海201620; [3]华中科技大学同济医学院附属协和医院血管外科,湖北武汉430022 |
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| 基金项目： | 湖北省教育厅重大项目（Z200717001） |
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| 摘 要： | 以自制的非水溶性丝素粉体为载体，将肝素与医用聚氨酯同溶液混合，制备出含有肝素的丝素／聚氨酯共混膜，解决了肝素与聚氨酯同溶液共混成膜时团聚的问题，并利用丝素蛋白良好的吸附和缓释功能，使肝素从共混膜中缓慢释放出来，达到相对长效的抗凝血效果。利用ATR—FTIR分析了肝素加入后丝素粉体、丝素／聚氨酯共混膜的红外光谱的变化，并对共混膜中肝素的缓释性能及共混膜在PBS溶液中浸泡48h前后的形貌变化进行了研究。
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| 关 键 词： | 聚氨酯 丝素 肝素 缓释性能 |
Preparation and Releasing Property of SFP/PU Blend Membrane Containing Heparin |
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| Affiliation: | XU Haiye, YANG Hongjun , WANG Weici , OUYANG Chenxi , XU Weilin. (1 Key Laboratory of Green Processing and Functionalisation of New Textile Materials, Ministry of Education, Wuhan University of Science and Engineering, Wuhan 430073, Hubei Province, China;2 College of Textile, Donghua University, Shanghai 201620, China ;3 Department of blood vessel, the Affiliated Union Hospital, Tongji Medica/College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China) |
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| Abstract: | A self-made silk-fibroin powder （SFP）, which was water-insoluble, was used as the carrier of heparin （HEP） to blend with polyurethane （PU） in the solvent of N, N- dimethyl formamide （DMF）. In this SFP/PU blend membrane containing HER on one hand, it solved the problem that agglomerations happened when HEP was blended dicretly with PU; in the other hand, silk-fibroin had the property of good absorption and releasing funtion that HEP can release lowly from the blend membrane, and so that it maintain relatively long-term anti-clotting effect. ATR-FTIR was used to analysis the change in the infrared spectrum when HEP was added, and the releasing property of HEP from the blend membrane and the morphology of the blend membrane when it was immersed in the PBS solution for 48h were studied. |
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| Keywords: | Polyurethane Silk-fibroin Heparin Releasing property |
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