| Abstract: | Production of magnamycin in different fermentation media by Streptomyces halstedii was studied to select the most suitable for the formation of the antibiotic. Two distinct phases were observed during the fermentative production of magnamycin. The first phase was characterised by vegetative growth, while the second phase was distinguished by formation of the antibiotic. The optimum initial pH value of the medium was 6.12. Glucose was used as carbon source. The best concentrations of glucose and starch supporting biosynthesis of magnamycin were 8.0 and 15.0 g/litre respectively. Soyabean meal was the most suitable organic nitrogen source. The most suitable concentrations of soyabean meal, yeast extract and corn steep liquor were 8.0, 2.0 and 16.0 g/litre respectively. |
