High Surface‐Enhanced Raman Scattering Performance of Individual Gold Nanoflowers and Their Application in Live Cell Imaging |
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| Authors: | Qi Li Yuanyuan Jiang Rongcheng Han Xiaolan Zhong Siyun Liu Zhi‐Yuan Li Yinlin Sha Dongsheng Xu |
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| Affiliation: | 1. Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, PR China;2. Single‐molecule and Nanobiology Laboratory, Department of Biophysics, School of Basic Medical Sciences and Biomed‐X Center, Peking University, Beijing 100191, PR China;3. Laboratory of Optical Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, PR China |
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| Abstract: | Molecular imaging techniques based on surface‐enhanced Raman scattering (SERS) face a lack of reproducibility and reliability, thus hampering its practical application. Flower‐like gold nanoparticles have strong SERS enhancement performance due to having plenty of hot‐spots on their surfaces, and this enhancement is not dependent on the aggregation of the particles. These features make this kind of particle an ideal SERS substrate to improve the reproducibility in SERS imaging. Here, the SERS properties of individual flower‐like gold nanoparticles are systematically investigated. The measurements reveal that the enhancement of a single gold nanoparticle is independent of the polarization of the excitation laser with an enhancement factor as high as 108. After capping with Raman signal molecules and folic acid, the gold nanoflowers show strong Raman signal in the living cells, excellent targeting properties, and a high signal‐to‐noise ratio for SERS imaging. |
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| Keywords: | gold nanoflowers surface‐enhanced Raman scattering Raman imaging live cell imaging |
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