Eradication of Multi‐Drug Resistant Bacteria by a Novel Zn‐doped CuO Nanocomposite |
| |
| Authors: | Eyal Malka Ilana Perelshtein Anat Lipovsky Yakov Shalom Livnat Naparstek Nina Perkas Tal Patick Rachel Lubart Yeshayahu Nitzan Ehud Banin Aharon Gedanken |
| |
| Affiliation: | 1. Bar‐Ilan University Center for Advanced Materials and Nanotechnology, Ramat‐Gan 52900, Israel;2. The Mina & Everard Goodman Faculty of Life Sciences, Bar‐Ilan University, Ramat‐Gan 52900, Israel;3. Department of Chemistry, Bar‐Ilan University, Ramat‐Gan 52900, Israel |
| |
| Abstract: | Zinc‐doped copper oxide nanoparticles are synthesized and simultaneously deposited on cotton fabric using ultrasound irradiation. The optimization of the processing conditions, the specific reagent ratio, and the precursor concentration results in the formation of uniform nanoparticles with an average size of ≈30 nm. The antibacterial activity of the Zn‐doped CuO Cu0.88Zn0.12O in a colloidal suspension or deposited on the fabric is tested against Escherichia coli (Gram negative) and Staphylococcus aureus (Gram positive) bacteria. A substantial enhancement of 10 000 times in the antimicrobial activity of the Zn–CuO nanocomposite compared to the pure CuO and ZnO nanoparticles (NPs) is observed after 10 min exposure to the bacteria. Similar activities are observed against multidrug‐resistant bacteria (MDR), (i.e., Methicillin‐resistant S. aureus and MDR E. coli) further emphasizing the efficacy of this composite. Finally, the mechanism for this enhanced antibacterial activity is presented. |
| |
| Keywords: | CuO ZnO doping nanoparticles multi‐drug resistance antibacterials nanocomposites |
|
|
