Photosensitizer–Gold Nanorod Composite for Targeted Multimodal Therapy |
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| Authors: | Jian Wang Mingxu You Guizhi Zhu Mohammed Ibrahim Shukoor Zhuo Chen Zilong Zhao Meghan B Altman Quan Yuan Zhi Zhu Yan Chen Cheng Zhi Huang Weihong Tan |
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| Affiliation: | 1. Center for Research at the Bio/Nano Interface, Department of Chemistry and Shands Cancer Center, University of Florida Genetics Institute, University of Florida, Gainesville, FL 32611‐7200, USA;2. Ministry of Education Key Laboratory on Luminescence and Real‐Time Analysis, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China;3. Molecular Sciences and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha 410082, China |
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| Abstract: | In this work, a DNA inter‐strand replacement strategy for therapeutic activity is successfully designed for multimodal therapy. In this multimodal therapy, chlorin e6 (Ce6) photosensitizer molecules are used for photodynamic therapy (PDT), while aptamer‐AuNRs, are used for selective binding to target cancer cells and for photothermal therapy (PTT) with near infrared laser irradiation. Aptamer Sgc8, which specifically targets leukemia T cells, is conjugated to an AuNR by a thiol‐Au covalent bond and then hybridized with a Ce6‐labeled photosensitizer/reporter to form a DNA double helix. When target cancer cells are absent, Ce6 is quenched and shows no PDT effect. However, when target cancer cells are present, the aptamer changes structure to release Ce6 to produce singlet oxygen for PDT upon light irradiation. Importantly, by combining photosensitizer and photothermal agents, PTT/PDT dual therapy supplies a more effective therapeutic outcome than either therapeutic modality alone. |
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| Keywords: | aptamer gold nanorods photosensitizer multimodal therapy |
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