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Polymersomes Containing a Hydrogel Network for High Stability and Controlled Release
Authors:Shin‐Hyun Kim  Jin Woong Kim  Do‐Hoon Kim  Sang‐Hoon Han  David A Weitz
Affiliation:1. School of Engineering and Applied Sciences, Department of Physics, Harvard University, Cambridge, MA 02138, USA;2. Department of Chemical and Biomolecular Engineering, KAIST, Daejeon, South Korea;3. Department of Applied Chemistry, Hanyang University, Ansan, South Korea;4. Amore‐Pacific Co. R&D Center, Yongin, South Korea
Abstract:Capillary microfluidic devices are used to prepare monodisperse polymersomes consisting of a hydrogel core and a bilayer membrane of amphiphilic diblock‐copolymers. To make polymersomes, water‐in‐oil‐in‐water double‐emulsion drops are prepared as templates through single‐step emulsification in a capillary microfluidic device. The amphiphile‐laden middle oil phase of the double‐emulsion drop dewets from the surface of the innermost water drop, which contains hydrogel prepolymers; this dewetting leads to the formation of a bilayer membrane. Subsequently, the oil phase completely separates from the innermost water drop, leaving a polymersome. Upon UV illumination of the polymersome, the prepolymers encapsulated within the interior are crosslinked, forming a hydrogel core. The hydrogel network within the polymersomes facilitates sustained release of the encapsulated materials and increases the stability of the polymersomes through the formation of a scaffold to support the bilayer. In addition, this approach provides a facile method to make monodisperse hydrogel particles directly dispersed in water.
Keywords:polymersomes  microfluidics  hydrogels  controlled release  emulsions
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