Dietary lipid modification of myocardial eicosanoids following ischemia and reperfusion in the rat |
| |
Authors: | Mahinda Y Abeywardena John S Charnock |
| |
Affiliation: | (1) Division of Human Nutrition, Glenthorne Laboratory, O'Halloran Hill, CSIRO, Gouger Street, P.O. Box 10041, 5158, SA, Australia |
| |
Abstract: | Several different edible oils were compared for their ability to modify eicosanoid biosynthesis following experimentally-induced
myocardial ischemia and reperfusion in the rat. Two types of palm oil neutralized, bleached, and deodorized (NBDPO) and refined,
bleached, and deodorized (RBDPO)] and partially hydrogenated soybean oil (SBO) were tested against a diet supplemented with
sunflower seed oil (SSO) rich in n−6 polyunsaturated fatty acids (PUFA). Fish oil (FO) rich in n−3 PUFA, with its known cardioprotective
actions, served as an internal reference point for the study. Test oils were fed as a 12% (w/w) supplement for nine months
before the induction of myocardial ischemia and reperfusion. Palm oil diets exerted effects indistinguishable from the SBO
group against cardiac arrhythmia, which occurred following alterations to coronary blood flow. Arrhythmic potentials, as expressed
by a hierarchical scale (0–9) of arrhythmia score, were: SSO, 1.5±0.5; FO, 0.9±0.4; SBO; 3.1±0.5*; NBDPO, 3.2±0.5*; RBDPO, 3.3±0.6*,*
P<0.05 vs. SSO. Following ischemia and reperfusion, both SSO and RBDPO groups tended to show an increase in myocardial prostacyclin,
with the effect being more prominent in the RBDPO group (SSO, 10%; RBDPO, 25%). Thromboxane production was reduced in the
FO group. Interestingly, cardiac muscle from both FO and palm oil groups displayed a reduced capacity to produce 12-hydroxyeicosatetraenoic
acid SSO, 591.9±95.8; SBO, 375.5±48.9; NBDPO, 287.2±64.7*; RBDPO, 230.9±80.2**; FO, 203.7±81.4** (ng/g dry wt,*
P<0.05,**
P<0.01). No clear relationship was seen between the availability of 20∶4n−6 in myocardial phospholipids and eicosanoid profile.
Data suggests that fatty acid composition of edible oils is not the only determinant of arrhythmic vulnerability and eicosanoid
production.
Based on a paper presented at the PORIM International Palm Oil Congress, Kuala Lumpur, Malaysia, September 1993. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|