Monte Carlo dosimetry for targeted irradiation of individual cells using a microbeam facility |
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| Authors: | Incerti, S. Seznec, H. Simon, M. Barberet, Ph. Habchi, C. Moretto, Ph. |
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| Affiliation: | 1 CNRS/IN2P3, Centre d'Etudes Nucléaires de Bordeaux-Gradignan, UMR 5797, Gradignan F-33175, France
2 Université de Bordeaux, Centre d'Etudes Nucléaires de Bordeaux-Gradignan, UMR 5797, Gradignan F-33175, France |
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| Abstract: | Microbeam facilities provide a unique opportunity to investigatethe effects of ionising radiation on living biological cellswith a precise control of the delivered dose. This paper describesdosimetry calculations performed at the single-cell level inthe microbeam irradiation facility available at the Centre d'EtudesNucléaires de Bordeaux-Gradignan in France, using theobject-oriented Geant4 Monte Carlo simulation toolkit. The cellgeometry model is based on high-resolution three-dimensionalvoxelised phantoms of a human keratinocyte (HaCaT) cell line.Such phantoms are built from confocal microscopy imaging andfrom ion beam chemical elemental analysis. Results are presentedfor single-cell irradiation with 3 MeV incident alpha particles. |
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