疫苗温度标签的制备及显色动力学

目的 以2,4-己二炔-1,6-二烷基脲为原料制备疫苗温度标签,并对其重结晶和共结晶的制备,以及显色动力学规律进行研究,为疫苗温度标签的商业化应用提供理论指导.方法 通过使用不同溶剂对2,4-己二炔-1,6-二乙基脲的重结晶,以及不同比例的2,4-己二炔-1,6-二乙基脲和2,4-己二炔-1,6-二丙基脲的共结晶进行实验,确定最适宜的配方,并对其显色动力学规律进行研究,利用分光密度仪对光密度值进行测定,进而通过计算得到反应活化能.结果 不同溶解度的溶剂重结晶2,4-己二炔-1,6-二乙基脲后的固相聚合反应速率不同,通过实验发现以m乙醇:m水=3:1的混合溶液为溶剂重结晶,以及mKE:mKPR=2:1共结晶得到的产物热反应性较好,颜色变化较为鲜明,且通过计算得到该固相聚合反应的活化能为31.94 kJ/mol.结论 将2,4-己二炔-1,6-二烷基脲作为新型的化学型疫苗温度标签,其视觉响应信号易于识别;通过重结晶和共结晶的改性来匹配不同种类的疫苗,可直观反映疫苗在冷链运输、保存和使用环节的质量.

Preparation and Color Kinetics of Vaccine Vial Monitor

The work aims to study the migration of volatile organic compounds in polystyrene foam boxes for fruits and vegetables and evaluate the safety of food after contact with foam boxes. The foam boxes from different sources were collected, and 4% (volume fraction) acetic acid and 10% (volume fraction) ethanol were used to simulate liquid migration experiments. Then the volatile organic compounds with higher migration were selected for physical migration experiments to detect the migration of volatile organic compounds. Meta-xylene, p-xylene, o-xylene, styrene, ethylbenzene, 1,3-butadiene had different degrees of migration detected in the migration experiment of the simulated liquid, and 10% (volume fraction) ethanol has a higher migration value as a migration solution, styrene has the highest migration in 10% (volume fraction) ethanol; o-xylene was not detected in oranges in physical migration experiments, and the migration of styrene in oranges increases with the temperature, the longer the storage time, and the greater the migration high. O-xylene was detected in Chinese cabbage, and the migration amount also showed an upward trend with the increase of temperature and time. The migration of volatile organic compounds was not detected in cherry tomatoes. The migration of styrene and o-xylene in the foam box in the simulated liquid is relatively high, and they may migrate in large quantities after being exposed to oranges and Chinese cabbage for a long time at higher temperature, posing risks to human health.