Liver and thymus lipid composition in AKR mice with and without lymphomas |
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| Authors: | Shinichi Kitada Lawrence Mwasi James F. Mead Esther F. Hays |
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| Affiliation: | (1) Laboratory of Nuclear Medicine and Radiation Biology, University of California, 90024 Los Angeles, California;(2) Department of Biological Chemistry, UCLA School of Medicine, 90024 Los Angeles, California;(3) Laboratory of Nuclear Medicine and Radiation Biology, University of California, 90024 Los Angeles, California;(4) Department of Medicine, UCLA School of Medicine, 90024 Los Angeles, California |
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| Abstract: | Lipid composition of liver and thymus in controls, early stage lymphoma, and advanced stage lymphoma-bearing AKR mice was studied. There was a significant decrease in the liver total lipid content in mice with advanced lymphoma, whereas in the early stages, no quantitative change was seen. In livers of mice with advanced stage lymphoma, there was a significant decrease in the nonpolar fraction. The decrease was in triglyceride, whereas the cholesterol fractions were relatively increased though highly variable. There was an increase in the polar lipid/nonpolar lipid ratio in the advanced lymphoma livers and a very large increase in the polar lipid/triglyceride ratio, indicating that the decrease in total lipid in these livers was largely in the triglyceride fraction. Similar changes were seen in the thymus, in which the lipid composition reflected the transformation from normal to malignant cells. |
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