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Cyanidin-3-glucoside ameliorates CCl4-induced liver injury in mice |
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| Authors: | Byoung Ok Cho Chang Wook Lee Yangkang So Chang Hyun Jin Si Yong Kang Dong Sub Kim Kwon Il Seo Hong Sun Yook Il Yun Jeong |
| Affiliation: | 1. Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Jeonbuk, 580-185, Korea 3. Department of Food Science and Human Nutrition, Chungnam National University, Daejeon, 305-764, Korea 2. Department of Food and Nutrition, Sunchon National University, Sunchon, Jeonnam, 540-742, Korea |
| Abstract: | The protective effect of cyanidin-3-glucoside (C3G) against carbon tetrachloride (CCl4)-induced liver injury in mice was investigated. Administration of C3G attenuated the levels of serum aspartate aminotransferase, alanine aminotransferase, and liver lipid peroxidation in CCl4-treated mice. Histopathological examination of mouse livers showed that C3G reduced the incidence of liver lesions induced by CCl4. Moreover, C3G prevented DNA damage and decreased the protein levels of γ-H2AX in CCl4-treated mouse livers. C3G also increased the activity of the antioxidant enzymes superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase, which were decreased due to CCl4 administration in CCl4-treated mouse livers. C3G inhibited the expression levels of IL-6 and iNOS in CCl4-treated mice. C3G apparently protects the liver from CCl4-induced hepatic damage through antioxidant and anti-inflammatory mechanisms. |
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