Poly(propylene)-based Films Modified with a Tetracationic Phthalocyanine with Applications in Photodynamic Inactivation of Candida albicans |
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| Authors: | Tomas Tempesti M Gabriela Alvarez César Gómez Miriam Strumia |
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| Affiliation: | 1. Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Argentina;2. Departamento de Química, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Río Cuarto, Córdoba, Argentina |
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| Abstract: | Photoactive films based on polymer-like poly(propylene) were generated and utilized as support of zinc(II)tetramethyltetrapyridino2,3-b:2′,3′-g:2″,3″-l:2″′,3″′-q]porphyrazinium salt (ZnTM2,3PyPz). Using a photograft polymerization of acrylic acid, the poly(propylene) film was functionalized with carboxyl groups (PP-g-PAAc), which attached ZnTM2,3PyPz by electrostatic bond to form PP-g-PAAc-Pc films. In vitro investigations indicated that PP-g-PAAc-Pc films produced photodynamic inactivation of Candida albicans cells, mainly mediated by a contribution of type II process. According to the results, the photodynamic activity produced by the PP-g-PAAc-Pc film and visible light irradiation can successfully inactivate C. albicans deposited on the surface of the films. |
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| Keywords: | Antimicrobial photoactive surface photodynamic inactivation phthalocyanine polymeric films |
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