An Insight on the Swelling,Viscoelastic, Electrical,and Drug Release Properties of Gelatin–Carboxymethyl Chitosan Hydrogels |
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Authors: | Preeti Madhuri Pandey Indranil Banerjee Arfat Anis |
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Affiliation: | 1. Department of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela, India;2. Department of Chemical Engineering, King Saud University, Riyadh, Saudi Arabia |
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Abstract: | The present study reports the in-depth analysis of the gelatin–carboxymethyl chitosan hydrogels. The composite system formed phase-separated hydrogels, which is confirmed by scanning electron microscopy. The swelling of the carboxymethyl chitosan-containing hydrogels was lower than the gelatin hydrogel. Macroscale deformation study using a static mechanical tester indicated a viscoelastic nature of the hydrogels. A decrease in the impedance of the hydrogels was observed with an increase in the carboxymethyl chitosan content. The drug release from the hydrogels was predominantly Fickian diffusion mediated and was released in its active form. The results suggested the potential use of the hydrogels as drug delivery matrices. |
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Keywords: | Carboxymethyl chitosan gelatin Peleg’s sorption model Peppas–Sahlin model Weichert model |
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