| Preparation and biological evaluation of ^99Tc^m-labelled fatty acids |
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| 引用本文： | LIANG Jixin HU Ji CHEN Baojun LUO Lianzhe LI Hongyu SHEN Langtao LUO Zhifu. Preparation and biological evaluation of ^99Tc^m-labelled fatty acids[J]. 核技术(英文版), 2007, 18(3): 159-163. DOI: 10.1016/S1001-8042(07)60039-6 |
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| 作者姓名： | LIANG Jixin HU Ji CHEN Baojun LUO Lianzhe LI Hongyu SHEN Langtao LUO Zhifu |
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| 作者单位： | Isotope Department, China Institute of Atomic Energy, Beijing 102413, China |
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| 基金项目： | Supported by the Co-ordinated Research Programme of the International Atomic Energy Agency （Contract No： 12469/R0） |
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| 摘 要： | The aim of the present work was to develop radiolabelling fatty acids based on ^99Tc^m carbonyl chemistry for heart imaging. Undecanoic acids functionalised with iminodiacetatic acid and cysteine were radiolabelled with [^99Tc^m（CO）3（H2O）3]^＋ intermediates, and their radiolabelling conditions were carefully studied. Biodistribution of ^99Tc^m（CO）3-CYST FAC 11 and ^99Tc^m（CO）3-IDA FAC 11 were observed in normal mice. The results showed that two ^99Tc^m-labelled compounds had similar profile in terms of high initial radioactivity uptake and rapid washout of radiotracers in the heart. ^99Tc^m （CO）3-IDA FACII was mainly excreted via hepatobiliary system in contrast to ^99Tc^m （CO）3-CYST FAC11, which was excreted from urinary system. It may be in part attributed to the more lipophilicity of ^99Tc^m （CO）3-IDA FAC11 than ^99Tc^m （CO）3-CYST FAC11.
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| 关 键 词： | 脂肪酸 放射性同位素 ^99Tc^m 医学应用 |
| 收稿时间： | 26 June 2006. |
| 修稿时间： | 2006-06-26 |
Preparation and biological evaluation of Tc-labelled fatty acids |
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| Jixin LIANG, Ji HU, Baojun CHEN, Lianzhe LUO, Hongyu LI, Langtao SHEN,Zhifu LUO. Preparation and biological evaluation of Tc-labelled fatty acids[J]. , 2007, 18(3): 159-163. DOI: 10.1016/S1001-8042(07)60039-6 |
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| Authors: | Jixin LIANG Ji HU Baojun CHEN Lianzhe LUO Hongyu LI Langtao SHEN Zhifu LUO |
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| Affiliation: | aIsotope Department, China Institute of Atomic Energy, Beijing 102413, China |
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| Abstract: | The aim of the present work was to develop radiolabelling fatty acids based on 99Tcm carbonyl chemistry for heart imaging. Undecanoic acids functionalised with iminodiacetatic acid and cysteine were radiolabelled with [99Tcm (CO)3(H2O)3] intermediates, and their radiolabelling conditions were carefully studied. Biodistribution of 99Tcm (CO)3-CYST FAC11 and 99Tcm (CO)3-IDA FAC11 were observed in normal mice. The results showed that two 99Tcm-labelled compounds had similar profile in terms of high initial radioactivity uptake and rapid washout of radiotracers in the heart. 99Tcm (CO)3-IDA FAC11 was mainly excreted via hepatobiliary system in contrast to 99Tcm (CO)3-CYST FAC11, which was excreted from urinary system. It may be in part attributed to the more lipophilicity of 99Tcm (CO)3-IDA FAC11 than 99Tcm (CO)3-CYST FAC11. |
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| Keywords: | 99Tcm-labelling Fatty acid derivatives Biodistribution |
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