| 对氯苯乙酸的合成 |
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| 引用本文： | 邹晓虹 聂少春 毛利民 郭 涛 李 毅. 对氯苯乙酸的合成[J]. 化学与生物工程, 2014, 0(3): 66-67 |
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| 作者姓名： | 邹晓虹 聂少春 毛利民 郭 涛 李 毅 |
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| 作者单位： | 武汉有机实业有限公司,湖北武汉430035 |
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| 摘 要： | 以对氯苯乙腈为原料直接经硫酸催化水解合成对氯苯乙酸,通过对传统工艺的重新设计,得到了适合工业化的新工艺,优化的合成条件为:硫酸质量分数60%~70%、反应时间3h、反应温度130~140℃,对氯苯乙酸收率达95%左右。
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| 关 键 词： | 对氯苯乙腈 对氯苯乙酸 水解 |
Synthesis of p-Chlorophenylacetate Acid |
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| ZOU Xiao-hong,NIE Shao-chun,MAO Li-ming,GUO Tao,LI Yi. Synthesis of p-Chlorophenylacetate Acid[J]. Chemistry & Bioengineering, 2014, 0(3): 66-67 |
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| Authors: | ZOU Xiao-hong NIE Shao-chun MAO Li-ming GUO Tao LI Yi |
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| Affiliation: | 1.Wuhan Organic Industrial Co.,Ltd.,Wuhan 430035,China;) |
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| Abstract: | p-Chlorophenylacetate acid was prepared by hydrolysis from p-chlorobenzyl cyanide catalyzed by sulfuric acid.By redesigning the traditional method,the process suitable for industrial manufacture was obtained,the optimal synthetic conditions were as follows：mass fraction of sulfuric acid of 60 ％ ～ 70 ％,reaction time of 3 h,reaction temperature of 130 ～ 140 ℃,and the yield of p-chlorophenylacetate acid reached about 95％. |
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| Keywords: | p-chlorobenzyl cyanide p-chlorophenylacetate acid hydrolysis |
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