呋喃酚环合反应研究

采用醇铝作为呋喃酚环合反应催化剂,研究催化剂用量与呋喃酚选择性的关系,以及在反应体系中添加或采出醇对反应收率的影响。结果表明,醇铝在催化单醚合成呋喃酚过程中,醇铝中的烷氧基与原料单醚和产物呋喃酚的芳氧基发生了交换,交换生成的醇与单醚或呋喃酚发生副反应降低了呋喃酚收率。探讨了呋喃酚环合反应质子酸催化机理。

Study on the Synthesis of Benzofaramol by Cyclization from Monoether

The synthesis of furan phenol through cyclization were studied, catalyzed by aluminium alkoxide and the affect of the catalyst weight against the selection of furan phenol and the feeding in or distilling out of the alcohol against the reaction yield of product. It was found that the alkoxy of the aluminium alkoxide can be exchanged to the arkoxy of the raw material or product in the process of reaction. The alcohol producing in the exchange reaction reduces the yield of furan phenol by the further by-reaction of the alcohol with the raw material or product. The mechanism was discussed in the proton acid catalytic reaction of furan phenol cyclization.