1-氯甲酰基-3-乙酰基咪唑烷酮合成新方法研究

采用乙酰基苯并三氮唑以及双（三氧甲基）碳酸酯作为原料，合成了酰脲类青霉素的关键中间体1-氯甲酰基-3-乙酰基咪唑烷酮。实验结果表明，合成中间产物乙酰基咪唑烷酮时，甲苯为溶剂时反应收率最高，使用K2CO3最适宜且n（咪唑烷酮）：n（K2CO3）=1：1时反应收率最高；合成1-氯甲酰基-3-乙酰基咪唑烷酮时，最适宜以氯仿为溶剂、三乙胺为催化剂，且n（乙酰基咪唑烷酮）：n（BTC）=1：0．45时收率最高。产品总收率达到80％。该方法反应条件温和、活性好、产品纯度高、收率高，并对环境友好。

A New Process for the Synthesis of 1-Chlorocarbonyl-3-acetyl imidazolidone

A key intermediate of penicilline 1-chlorocarbonyl-3-acetyl imidazolidone is synthesized with n-acetylbenzotriazoles and bis-(trichloromethyl) carbonate as the raw materials. Experimental results show that the best conditions for the synthesis of the intermediate 1-acetyl imidazolidone-2-one are as follows: toluene as the solvent, K2CO3 as the base, and n(imidazolidinone):n(K2CO3)=1:1. And the best conditions for the synthesis of 1-chlorocarbonyl-3-acetyl imidazolidone were: Chloroform as the solvent, triethylamine as the catalyst, and n(1-acetyl imidazolidone -2-one):n(BTC)=1:0.45. Total yield of the reaction is 80%. The process is of moderate conditions, good activity, high purity and high yield, and is friendly to the environment.