| 心脏微环境的改变对瞬时外向钾电流的影响 |
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| 引用本文： | 杜智敏,任南琪,单宏丽,焦军东.心脏微环境的改变对瞬时外向钾电流的影响[J].哈尔滨工业大学学报,2006,38(1):22-25. |
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| 作者姓名： | 杜智敏 任南琪 单宏丽 焦军东 |
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| 作者单位： | 哈尔滨工业大学,市政环境工程学院,黑龙江,哈尔滨,150001;哈尔滨医科大学附属二院,临床药物研究所,黑龙江,哈尔滨,150086;哈尔滨工业大学,市政环境工程学院,黑龙江,哈尔滨,150001;哈尔滨医科大学,药学院,黑龙江,哈尔滨,150086 |
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| 摘 要： | 采用氮气饱和、改变溶液pH值及结扎冠状动脉等方法改变心室肌细胞微环境,应用全细胞膜片钳技术记录犬单个心室肌细胞瞬时外向钾电流(Ito),观察犬心室肌细胞瞬时外向钾电流在细胞内外液环境影响下的改变.研究发现犬心肌细胞跨膜离子流Ito在心肌微环境变化,如缺血、pH值改变时,上述电流发生时明显变化.心脏微环境变化,犬心室肌细胞瞬时外向钾电流发生明显减低,这可能与缺血性心律失常发展有关.
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| 关 键 词： | 微环境 氮气 pH 缺血 瞬时外向钾电流 |
| 文章编号： | 0367-6234(2006)01-0022-04 |
| 收稿时间： | 2005-01-10 |
| 修稿时间： | 2005年1月10日 |
Effects of microenvironmental change on transient outward potassium currents |
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| DU Zhi-min,REN Nan-qi,SHAN Hong-li,JIAO Jun-dong.Effects of microenvironmental change on transient outward potassium currents[J].Journal of Harbin Institute of Technology,2006,38(1):22-25. |
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| Authors: | DU Zhi-min REN Nan-qi SHAN Hong-li JIAO Jun-dong |
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| Affiliation: | 1. School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150090, China,;2. Institute of Clinical Pharmacology of Second Hospital, Harbin Medical University, Harbin 150086, China; 3. Dept. of Pharmacology of School Pharmacy, Harbin Medical University, Harbin 150086, China |
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| Abstract: | The microenvironment was changed using a perfusion solution in NO saturated gas and decreased pH value as well as coronary artery ligation in a dog.The patch clamp technique was used in the experiment.The effects of the microenvironment changed with the transient outward potassium currents(I_(to)) in canine cardiomyocyte.It was found that the change of microenvironments,such as ischemia and lower pH value,significantly decreased the Ito in the canine ventricular single cell.The result demonstrated that the changes of the microenvironment affected Ito significantly which is related to the ischemic arrhythmias. |
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| Keywords: | microenvironment NO pH ischemia I_(to) |
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