Scanning tunneling microscopy study of cytochrome P450 2B4 incorporated in proteoliposomes |
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| Authors: | Uvarov VYu YD Ivanov AN Romanov MO Gallyamov OI Kiselyova IV Yaminsky |
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| Affiliation: | Laboratory of Physico-Chemical Methods of Analysis, Institute of Biomedical Chemistry, Moscow, Russia. |
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| Abstract: | In the present paper, the application of scanning tunneling microscopy in cytochrome P450s membrane topology is discussed. The method enables visualization of heme location in the lipid-bilayer-incorporated protein. It is supposed that the membrane-bound cytochrome P450 on the tunneling microscope substrate should behave as 'molecular diode'. A model explaining the liposome and the proteoliposome images observed is proposed. |
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