Lipid peroxidation during n−3 fatty acid and vitamin E supplementation in humans |
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Authors: | Johane P Allard Regina Kurian Elaheh Aghdassi Reto Muggli Dawna Royall |
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Affiliation: | (1) Department of Medicine, University of Toronto, M5G 2C4 Toronto, Ontario, Canada;(2) The Toronto Hospital-General Division, 200 Elizabeth St. 9 EN-217A, M5G 2C4 Toronto, Ontario, Canada;(3) Present address: F. Hoffmann-La Roche Ltd., Basel, Switzerland |
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Abstract: | The purpose of this study was to investigate in healthy humans the effect of eicosapentaenoic acid (EPA) and docosahexaenoic
acid (DHA) intake, alone or in combination with dL-α-tocopherol acetate (vitamin E) supplements on lipid peroxidation. Eightly
men were randomly assigned in a double-blind fashion to take daily for 6 wk either menhaden oil (6.26 g, n−3 fatty acids)
or olive oil supplements with either vitamin E (900 IU) or its placebo. Antioxidant vitamins, phospholipid composition, malondialdehyde
(MDA), and lipid peroxides were measured in the plasma at baseline and week 6. At the same time, breath alkane output was
measured. Plasma α-tocopherol concentration increased in those receiving vitamin E (P<0.0001). In those supplemented with n−3 fatty acids, EPA and DHA increased in plasma phospholipids (P<0.0001) and plasma MDA and lipid peroxides increased (P<0.001 and P<0.05, respectively). Breath alkane output did not change significantly and vitamin E intake did not prevent the increase
in lipid peroxidation during menhaden oil supplementation. The results demonstrate that supplementing the diet with n−3 fatty
acids resulted in an increase in lipid peroxidation, as measured by plasma MDA release and lipid peroxide products, which
was not suppressed by vitamin E supplementation. |
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