| 氟氯交换氟化合成对氟苯甲醛 |
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| 引用本文： | 吕早生,余腾飞,张琳涵,赵金龙,黄吉林,胡亚.氟氯交换氟化合成对氟苯甲醛[J].湖北化工,2012(1):54-56. |
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| 作者姓名： | 吕早生 余腾飞 张琳涵 赵金龙 黄吉林 胡亚 |
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| 作者单位： | 武汉科技大学化学工程与技术学院,湖北武汉430081 |
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| 摘 要： | 以对氯苯甲醛（PCAD）和氟化钾为原料、以硝基苯和环丁砜（TMSO2）为溶剂、以四苯基溴化（Ph4PBr）和四乙二醇二甲醚（C10H22O5）为复合催化体系,直接氟化制得对氟苯甲醛。优化的工艺条件为：n（KF）∶n（PCAD）∶n（Ph4PBr）∶n（C10H22O5）=4∶1∶0.15∶0.05、反应温度210℃、反应时间8h,在此条件下对氟苯甲醛的收率为88.2%、转化率为92.8%、选择性为95.1%。
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| 关 键 词： | 复合溶剂 卤素交换氟化 对氟苯甲醛 |
Synthesis of 4-Fluorobenzaldehyde by F-Cl Exchange Fluorination |
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| Lü Zao-sheng,YU Teng-fei,ZHANG Lin-han,ZHAO Jin-long,HUANG Ji-lin,HU Ya.Synthesis of 4-Fluorobenzaldehyde by F-Cl Exchange Fluorination[J].Hubei Chemical Industry,2012(1):54-56. |
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| Authors: | Lü Zao-sheng YU Teng-fei ZHANG Lin-han ZHAO Jin-long HUANG Ji-lin HU Ya |
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| Affiliation: | (College of Chemical Engineering and Technology,Wuhan University of Science and Technology,Wuhan 430081,China) |
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| Abstract: | Using Ph4PBr and C10H22O5 as synergism catalyst,nitrobenzene and TMSO2 as synergism solvent,4-fluorobenzaldehyde was prepared by halogen-exchange fluorination of 4-chlorobenzaldehyde（PCAD） with spray-dried KF.The optimum reaction conditions were obtained as follows：n（KF）∶n（PCAD）∶n（Ph4PBr）∶n（C10H22O5）=4∶1∶0.15 ∶0.05,reaction temperature 210 ℃,reaction time 8 h.Under above conditions,4-fluorobenzaldehyde was obtained with 88.2% yield,92.8% conversion,95.1% selectivity. |
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| Keywords: | synergism solvent halogen-exchange fluorination 4-fluorobenzaldehyde |
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