海苔发酵提取物对原发性高血压大鼠的降压效果研究

使用可以产生GABA的植物性乳酸菌对海苔进行发酵,得到富含10.5%GABA的海苔发酵提取物。本实验验证了海苔发酵提取物对原发性高血压模型大鼠(SHR)的降压效果。单次经口灌胃给药实验中,分别以2mg/kg·bw和0.2mg/kg·bw剂量的海苔发酵提取物一次性灌胃给药,给药后2、5、9、24h进行血压测定。结果表明,海苔发酵提取物2mg/kg·bw剂量组在给药后5h和24h均有显著降压效果(p<0.05,p<0.01)。长期摄食给药实验中,含有海苔发酵提取物0.001%和0.003%的饲料剂量组对成长期SHR和老龄期SHR分别摄食给药,给药后每2～3d进行一次血压和体重测量,结果显示含有海苔发酵提取物0.003%的饲料剂量组使成长期SHR和老龄期SHR血压均显著下降(p<0.01,p<0.05)。

Study on effect of Porphyra extract on blood pressure in spontaneously hypertensive rats

We used Lactobacillus brevis that could produce GABA to ferment Porphyra and we got the Porphyra extract(Pe),containing 10.5% γ-aminobutyric acid(GABA).The effect of Porphyra extract on blood pressure in spontaneously hypertensive rats(SHRs) was examined.A single medication at different doses of Porphyra extract(2mg/kg·bw and 0.2mg/kg·bw) were intragastic administered.After administration,blood pressure was measured at 2,5,9,24h.And the dose of Pe(2mg/kg·bw of rat weight) in SHRs showed a significant reduction in systolic blood pressure compared to the control group(p<0.05,p<0.01).While long term medication,groupth phase SHRs and gerontic SHRs were separately fed a diet containing Pe at the level of 0.003% and 0.001%.After administration,blood pressure and body weight were determined every 2 or 3 days.Finally,groupth phase SHRs and gerontic SHRs at the level of 0.003% also showed a significantly lowered blood pressure compared to the control group(p<0.01,p<0.05).