| 淡豆豉异黄酮浓缩物对大鼠胰岛素抵抗的改善作用 |
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| 引用本文： | 刘姣,田义龙,李琛,窦玉红,牛丽颖,王鑫国. 淡豆豉异黄酮浓缩物对大鼠胰岛素抵抗的改善作用[J]. 食品工业科技, 2012, 33(10): 347-348,361 |
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| 作者姓名： | 刘姣 田义龙 李琛 窦玉红 牛丽颖 王鑫国 |
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| 作者单位： | 河北医科大学中医学院,河北省实验动物重点实验室,河北石家庄050091 |
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| 基金项目： | 河北省自然科学基金资助项目(C2009001061);河北科学技术研究与发展计划项目(11231005D) |
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| 摘 要： | 目的:观察淡豆豉异黄酮浓缩物对大鼠胰岛素抵抗(IR)的改善作用。方法:采用高糖高脂饲料喂养加小剂量链脲佐菌素(STZ)腹腔注射的方法建立IR大鼠模型,8周后测定糖耐量(GTT),留取空腹血清测定血糖(FPG)、胰岛素(FINS)和糖化血红蛋白(GHb),计算胰岛素敏感指数(ISI)。结果:淡豆豉异黄酮浓缩物能明显改善IR大鼠GTT,明显降低FPG,FINS和GHb,显著增加ISI。结论:淡豆豉异黄酮浓缩物对大鼠胰岛素抵抗有明显的改善作用。
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| 关 键 词： | 淡豆豉异黄酮浓缩物 胰岛素抵抗 胰岛素 糖化血红蛋白 胰岛素敏感指数 |
Ameliorative effect of isoflavone concentrates of semen sojae preparatum on insulin resistance rats |
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| LIU Jiao,TIAN Yi-long,LI Chen,DOU Yu-hong,NIU Li-ying,WANG Xin-guo. Ameliorative effect of isoflavone concentrates of semen sojae preparatum on insulin resistance rats[J]. Science and Technology of Food Industry, 2012, 33(10): 347-348,361 |
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| Authors: | LIU Jiao TIAN Yi-long LI Chen DOU Yu-hong NIU Li-ying WANG Xin-guo |
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| Affiliation: | (Traditional Chinese Medical College,Hebei Medical University,Hebei Key Laboratory of Experimental Animals,Shijiazhuang 050091,China) |
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| Abstract: | Objective:To observe the ameliorative effect of isoflavone concentrate of semen sojea perparatum(ICS)on insulin resistance(IR)rats.Methods:The model of IR rats were induced by feeding high glucose-lipoids animal feeds and injecting low dose streptozotocin(STZ)intraperitoneally.After 8 weeks,glucose tolerance test(GTT)was measured,then fasting plasma glucose(FPG),fasting serum insulin(FINS)and glycosylated hemoglobin(GHb)were measured,then insulin sensitivity index(ISI)was calculated.Results:ICS could significantly ameliorate GTT of IR rats,lower FPG,FINS and GHb,and higher ISI.Conclusions:The ICS had an obvious ameliorative effect on IR rats. |
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| Keywords: | isoflavone concentrate of semen sojea perparatum insulin resistance fasting serum insulin glycosylated hemoglobin insulin sensitivity index |
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