The genetics of age-related macular degeneration

Age-related macular degeneration (ARM) is a progressive, chronic condition that results when the macula degenerates and central vision is lost. ARM is the leading cause of vision loss in Americans over age 50 and is a major public health concern. Very little is known about the etiology of ARM. Deciphering the genetic susceptibility associated with ARM holds great promise for gaining a better understanding of the disease, identifying at-risk individuals, and developing interventions and treatments.