Predicting the outcome in elderly patients of hospital admission for acute care in Paris, France: construction and initial validation of a simplex index |
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Authors: | M Zureik P Lombrail A Davido JL Trouillet B Tran A Levy T Lang |
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Affiliation: | Division of Nephrology, Dialysis and Hypertension and Postgraduate School of Nephrology, University of Milano, S. Raffaele Hospital, Italy. |
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Abstract: | An update on renal genetic mechanisms of spontaneous hypertension in rats and in human essential hypertension is presented. The findings are discussed, highlighting the search of a possible link between the discovered genetic abnormality and the renal function changes that may determine the disease. The analogies (and/or differences) between the numerous positive findings obtained in animal models and the relatively scarce ones obtained in humans are discussed. |
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