Induction of long-lasting hypercholesterolemia in the rat fed a cystine-enriched diet |
| |
Authors: | C Sérougne D Mathé C Lutton |
| |
Affiliation: | (1) Laboratoire de Physiologie de la Nutrition-Batiment 447, CNRS UA 646, Université de Paris-Sud, 91405 ORSAY Cedex, France;(2) Unité de Recherches sur les dyslipidémies et l'athérosclérose (U 32), Hopital Henri Mondor, 94010 CRETEIL, France |
| |
Abstract: | The influence of dietary excess (5%) of L-cystine on rat plasma lipoproteins was examined. After only one week of cystine
feeding, an increase in the plasma cholesterol level and a decrease in triglyceride levels were observed. The increase in
cholesterol level became greater when the duration of cystine-enriched diet increased until eight weeks (+131% after eight
weeks), but no further increase occurred between 8 and 20 weeks. This change was essentially due to the progressive increase
in cholesterol levels in high density lipoproteins (HDL) and in lipoproteins isolated between 1.040 and 1.063 g/ml, i.e.,
certain low density lipoproteins (HDL2), and containing mainly apoE-rich lipoproteins (HDL1). The decrease in plasma triglycerides resulted from that of chylomicrons and very low density lipoproteins (VLDL). The effects
observed after four or eight weeks of cystine feeding were maintained for eight weeks after replacing the cystine diet by
the standard diet. Ingestion of the standard diet containing either cholestyramine (2%) or probucol (0.25%) following eight
weeks of cystine feeding significantly decreased plasma cholesterol levels. It is concluded that cystine-fed rats are a useful
tool of investigation for understanding mechanisms leading to increased plasma cholesterol level and for hypocholesterolemic
drug trials. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|