Synthesis of NaYF4:20% Yb3+,2% Er3+,2% Ce3+@NaYF4 nanorods and their size dependent uptake efficiency under flow condition |
| |
| Affiliation: | 1. Fujian Normal University, Fuzhou 350007, China;2. CAS Key Laboratory of Design and Assembly of Functional Nanostructures, and Fujian Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China;3. Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Haixi Institutes, Chinese Academy of Sciences, Xiamen 361021, China;4. College of Materials Science and Engineering, Huaqiao University, Xiamen 361021, China;5. Research Center of Biomedical Engineering of Xiamen & Key Laboratory of Biomedical Engineering of Fujian Province & Fujian Provincial Key Laboratory for Soft Functional Materials Research, Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, China;6. Centre D''Elaboration de Matériaux et D''Etudes Structurales (CEMES), CNRS, Université de Toulouse - UPS, 29 Rue Jeanne Marvig, BP 94347, 31055, Toulouse, Cedex 4, France |
| |
| Abstract: | Lanthanide doped fluorescent nanoparticles have gained considerable attention in biomedical applications. However, the low uptake efficiency of nanoparticles by cells has limited their applications. In this work, we demonstrate how the uptake efficiency is affected by the size of nanoparticles under flow conditions. Using the same size NaYF4:20% Yb3+,2% Er3+,2% Ce3+ (the contents of rare earths elements are in molar fraction) nanoparticles as core, NaYF4:20% Yb3+,2% Er3+,2% Ce3+@NaYF4 core–shell structured nanorods (NRs) with different sizes of 60–224 nm were synthesized by thermal decomposition and hot injection method. Under excitation at 980 nm, a strong upconversion green emission (541 nm, 2H11/2 → 4I15/2 of Er3+) is observed for all samples. The emission intensity for each size nanorod was calibrated and is found to depend on the width of NRs. Under flow conditions, the nanorods with 96 nm show a maximum uptake efficiency by endothelial cells. This work demonstrates the importance of optimizing the size for improving the uptake efficiency of lanthanide-doped nanoparticles. |
| |
| Keywords: | Uptake efficiency Endothelial cells Upconversion luminescence Cell imaging Rare earths |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
