Poly(hydroxybutyrate‐co‐hydroxyvalerate) and bovine serum albumin blend prepared by electrospinning |
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| Authors: | Elizaveta R. Pavlova Dmitry V. Bagrov Maria N. Kopitsyna Dmitry A. Shchelokov Anton P. Bonartsev Irina I. Zharkova Tatiana K. Mahina Vera L. Myshkina Galina A. Bonartseva Konstantin V. Shaitan Dmitry V. Klinov |
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| Affiliation: | 1. Federal Research Clinical Center of Physical‐Chemical Medicine of the Federal Medical and Biological Agency of Russia, Moscow, Russian Federation;2. Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russian Federation;3. Department of Bioengineering, Faculty of Biology, Lomonosov Moscow State University, Moscow, Russian Federation;4. Bauman Moscow State Technical University, Moscow, Russian Federation;5. A. N. Bach Institute of Biochemistry RAS, Moscow, Russian Federation |
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| Abstract: | Electrospinning is a method for the preparation of nanosized polymer fibers. Here, electrospinning is used to prepare a blend of a polyester, poly(hydroxybutyrate‐co‐hydroxyvalerate) (PHBV), and a globular protein, bovine serum albumin (BSA). The electrospun blend film is compared with a solution‐cast blend film and with single‐component electrospun films made of PHBV and BSA. In the electrospun blend films, BSA manifests itself as flat ribbons and a fine network formed from fibers less than 50 nm in diameter. The dissolution rate of BSA from the electrospun blended film is lower than from the solution‐cast one. The films are characterized using scanning electron microscopy, differential scanning calorimetry, and contact‐angle measurements. The obtained PHBV+BSA blend films have several emergent properties: a slow BSA dissolution rate, a fine BSA network, and unusual thermal behavior. Thus, the PHBV+BSA blend films introduce a new class of polymer–protein blends. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134, 45090. |
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| Keywords: | biomaterials blends fibers microscopy phase behavior |
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