丙二酸亚异丙酯的单取代Mannich反应 |
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引用本文: | 黄少云,王福来. 丙二酸亚异丙酯的单取代Mannich反应[J]. 化学试剂, 2002, 24(5): 287-289 |
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作者姓名: | 黄少云 王福来 |
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作者单位: | 1. 武汉化工学院制药系,武汉,430074 2. 武汉大学化学系,武汉,430072 |
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摘 要: | 研究了丙二酸亚异丙酯与脂肪族胺的单取代曼尼希反应,通过对曼尼希碱的IR、UV、^HNMR及元素分析表征了其结构,发现其生成的曼尼希碱主要以内盐式存,改进丙二酸亚异丙酯的合成条件,使产率达到82.8%.
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关 键 词: | 单取代Mannich反应 丙二酯亚异丙酯 曼尼希反应 结构 脂肪族胺 曼尼希碱 |
文章编号: | 0258-3283(2002)05-0287-03 |
修稿时间: | 2002-01-11 |
Single substitution Mannich reaction of iso-propylidene malonate |
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Abstract: | Mannich reaction was carried out between iso-propylidene malonate and aliphatic amines under mild condition.The structures of Mannich bases were confirmed by elementary analysis,IR, 1HNMR and UV spectroscopies.Conditions for the synthesis of iso-propylidene malonate was improved with a yield of 82.8%,higher than 49% reported previously. |
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Keywords: | iso-propylidene malonate Mannich reaction structure |
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