Human disposition of L-theanine in tea or aqueous solution |
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Authors: | PC van der Pijl L Chen TPJ Mulder |
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Affiliation: | 1. Unilever Research and Development Vlaardingen, Olivier van Noortlaan 120, P.O. Box 114, 3130 AC, Vlaardingen, The Netherlands;2. Unilever Research Shanghai, 99 Tianzhou Road, Shanghai 200233, China |
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Abstract: | After consumption of tea, L-theanine enters systemic circulation and is assumed to enter the brain. Several human studies indicate that L-theanine influences brain functioning. Knowledge about the pharmacokinetics of L-theanine facilitates further study of this health effect. Volunteers received 25–100 mg of L-theanine as tea, as L-theanine-enriched tea, and as biosynthetic L-theanine in aqueous solutions. Plasma was analysed for L-theanine content after which data were fitted with a 1- compartment model. For all interventions, the lag time was approximately 10 min and half-lives of absorption and elimination were approximately 15 and 65 min respectively. After approximately 50 min, maximum plasma concentrations of between 1.0 and 4.4 mg/L were achieved. Maximum plasma concentration and area under the plasma-concentration–time curve were dose-proportional. This knowledge allows prediction of plasma concentrations for various dose regimens supporting further study of a health benefit of L-theanine. |
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