Synergistic effect enhances the peroxidase-like activity in platinum nanoparticle-supported metal—organic framework hybrid nanozymes for ultrasensitive detection of glucose
摘 要：
Synergistic effect enhances the peroxidase-like activity in platinum nanoparticle-supported metal-organic framework hybrid nanozymes for ultrasensitive detection of glucose
Li,Jing,Zhao,Jie,Li,Shengqiang,Chen,Yang,Lv,Weiqiang,Zhang,Jiahui,Zhang,Libing,Zhang,Zhen,Lu,Xiaoquan. Synergistic effect enhances the peroxidase-like activity in platinum nanoparticle-supported metal-organic framework hybrid nanozymes for ultrasensitive detection of glucose[J]. Nano Research, 2021, 14(12): 4689-4695. DOI: 10.1007/s12274-021-3406-z
Tianjin Key Laboratory of Molecular Optoelectronic,Department of Chemistry,School of Science,Tianjin University,Tianjin 300072,China;First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300000,China;School of Physics,University of Electronic Science and Technology,Chengdu 611731,China;Tianjin Key Laboratory of Molecular Optoelectronic,Department of Chemistry,School of Science,Tianjin University,Tianjin 300072,China;Key Laboratory of Bioelectrochemistry & Environmental Analysis of Gansu Province,College of Chemistry & Chemical Engineering,Northwest Normal University,Lanzhou 730070,China
Abstract:
The metal—organic frameworks (MOFs) are expected as ideal biomimetic enzymes for colorimetric glucose detection because of their large surface areas, well defined pore structures, tunable chemical composition, and multi-functional sites. However, the intrinsically chemical instability and low mimetic enzyme activity of MOFs hinder the application of them in imitating the enzyme reactions. In this work, we demonstrated a metal-MOF synergistic catalysis strategy, by loading Pt nanoparticles (Pt NPs) on MIL-88B-NH2 (Fe-MOF) to increase peroxidase-like activity for the detection of glucose. The induced electrons transfer from Pt atom to Fe atom accelerated the redox cycling of Fe3+/Fe2+, improved the overall efficiency of the peroxidase-like reaction, and enabled the efficient and robust colorimetric glucose detection, which was proved by both experiments and density functional theory (DFT) calculation. Additionally, the sensitivity and chemical stability of this synergistic effect strategy to detect the glucose are not affected by the complex external factors, which represented a great potential in fast, easy, sensitive, and specific recognition of clinical diabetes.
