| 2-氨基-5-芳基-1,3,4-噻二唑的合成 |
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| 引用本文： | 刘玉婷,周英,尹大伟.2-氨基-5-芳基-1,3,4-噻二唑的合成[J].精细石油化工,2011,28(1):61-63. |
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| 作者姓名： | 刘玉婷 周英 尹大伟 |
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| 作者单位： | 陕西科技大学教育部轻化工助剂化学与技术重点实验室,陕西,西安,710021;陕西科技大学化学与化工学院,陕西,西安,710021 |
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| 基金项目： | 陕西省自然科学基础研究计划重点项目 |
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| 摘 要： | 实验以不同取代苯甲酸与氨基硫脲、三氯氧磷为原料,经改进合成一系列5-芳基-2-氨基-1,3,4-噻二唑.讨论了工艺条件对收率的影响.实验结果表明,其最佳合成工艺条件为:三氯氧磷为12 mL,n(取代基苯甲酸):n(氨基硫脲)=1.0:1.2,反应加水量15 mL,反应温度80℃,反应时间120 min,收率均在85%以...
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| 关 键 词： | 2-氨基-5-芳基-1 3 4-噻二唑 合成 改进 取代苯甲酸 氨基硫脲 |
SYNTHESIS OF 2-AMINO-5-ARYL-1,3-THIADIAZOLES |
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| Liu Yuting,Zhou Ying,Yin Dawei.SYNTHESIS OF 2-AMINO-5-ARYL-1,3-THIADIAZOLES[J].Speciality Petrochemicals,2011,28(1):61-63. |
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| Authors: | Liu Yuting Zhou Ying Yin Dawei |
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| Abstract: | 5-Aryl-1,3,4-thiadiazol-2-amine derivatives were synthesized by different substituted benzoic acid,thiosemicarbazide and phosphorus oxychloride.The optimum conditions were obtained as follows:12 mL phosphorus oxychloride,n(Substituted benzoic acid):n(Thiosemicarbazide) = 1.0: 1.2,15 mL water,reaction temperature 80℃,and reaction time 120 min.Under the optimum conditions, the yield was up to 85%.The structures of the product were characterized by IR. |
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| Keywords: | 2-amino-5-aryl-1 3 4- thiadiazole synthesis improved substituted benzoic acid thiosemicarbazide and phosphorus oxychloride |
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