Interaction of histone H1 with cis-platinum modified DNA |
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| Authors: | EG Paneva NC Spassovska KC Grancharov JS Zlatanova JN Yaneva |
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| Affiliation: | Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria. |
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| Abstract: | Cis-diamminedichloroplatinum(II) (cis-DDP) is known as an effective anticancer drug. Its therapeutic effect is supposed to be a consequence of the covalent binding to DNA. A number of cellular proteins were found to bind selectively to DNA modified by cis-DDP (but not by its isomer trans-DDP). Here we present our observations on interaction of the linker histone H1 with cis- and trans-DDP modified DNA fragments. The results afford new experimental information about the preferential binding of histone H1 to cis-DDP-distorted DNAs versus trans-DDP modified ones. |
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