Preparation and characterization of pH responsive poly(methacrylic acid‐acrylamide‐N‐hydroxyethyl acrylamide) hydrogels for drug delivery systems |
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| Authors: | Ayça Bal Bengi Özkahraman Zehra Özbaş |
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| Affiliation: | 1. Faculty of Engineering, Department of Chemical Engineering, Istanbul University, Avc?lar, Istanbul, Turkey;2. Faculty of Engineering, Department of Polymer Engineering, Hitit University, ?orum, Turkey;3. Faculty of Engineering, Department of Chemical Engineering, ?ank?r? Karatekin University, ?ank?r?, Turkey |
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| Abstract: | In this study, pH responsive polymers composed of methacrylic acid, acrylamide, and N‐hydroxyethyl acrylamide were synthesized by free radical polymerization technique. The characterization was done with Fourier transform infrared spectroscopy and scanning electron microscopy. The swelling and drug release behavior of the hydrogels was determined as a function of time at 37°C in pH 2.1 and 7.4. The swelling and drug release studies showed that increased methacrylic acid amount caused a higher increase in swelling and drug release values at pH 7.4 than those at pH 2.1. In addition, the drug release data were applied to kinetic models such as zero order, first order, and Higuchi equations, and it fit well in the Higuchi model of the hydrogel. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133, 43226. |
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| Keywords: | adsorption copolymers drug delivery systems gels kinetics |
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