| 微波辅助下3-(甲氧基羰基甲基)替加氟的绿色合成 |
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| 引用本文： | 徐绍红,张伟. 微波辅助下3-(甲氧基羰基甲基)替加氟的绿色合成[J]. 化工时刊, 2008, 22(4): 32-34 |
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| 作者姓名： | 徐绍红 张伟 |
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| 作者单位： | 新乡学院化学与环境工程学院,河南,新乡,453003;新乡学院化学与环境工程学院,河南,新乡,453003 |
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| 摘 要： | 以氯乙酸和甲醇为原料，在无溶剂和250W微波辐射条件下，反应10min，生成氯乙酸甲酯，产率91．0％。随后以水为溶剂、四丁基溴化铵为相转移催化剂，在250W微波辐射20min条件下，快速合成中间体3-（甲氧基羰基甲基）替加氟，产率76．5％，产物结构经IR，^1H—NMR，HRMS表征。
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| 关 键 词： | 微波 3-(甲氧基羰基甲基)替加氟 氯乙酸甲酯 合成 |
| 修稿时间： | 2008-03-05 |
The Green Synthesis of 3-(methyloxycarbonyl) tegafur under Microwave Irradiation |
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| Xu Shaohong,Zhang Wei. The Green Synthesis of 3-(methyloxycarbonyl) tegafur under Microwave Irradiation[J]. Chemical Industry Times, 2008, 22(4): 32-34 |
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| Authors: | Xu Shaohong Zhang Wei |
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| Affiliation: | (Chemistry and Environment Engineering Department,Xinxiang University, Henan Xinxiang 453007) |
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| Abstract: | Methyl acetic acid was synthesized from acetic acid and methanol at solvent -free conditions under microwave irradiation, within 10 min, the yield was up to 91.1%. Then, using water as solvent and TBAB as phase transfer catalyst, N3 - （methyloxycarbonyl） tegafur was synthesized from tegafur and methyl acetic acid under microwave irradiation within 20 min. The reported method was green and efficient, and the yield was up to 76.5%. The compounds were characterized by IR, 1H- NMR, HRMS. |
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| Keywords: | Microwave irradiation 3 - （methyloxycarbonyl） tegafur Methyl acetic acid Synthesis |
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