| 2-氨基-4-氯吡啶的合成研究 |
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| 引用本文： | 廖建桥.2-氨基-4-氯吡啶的合成研究[J].精细化工中间体,2010,40(6). |
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| 作者姓名： | 廖建桥 |
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| 作者单位： | 浙江金明药业有限公司,浙江,三门,317100 |
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| 摘 要： | 以4-氯吡啶-2-甲酸甲酯为起始原料,经过肼解、重氮化及重排反应合成了2-氨基-4-氯吡啶,3步反应总收率68.56%。产品经1H NMR和MS表征。该方法具有操作简单等优点,适合工业化生产。
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| 关 键 词： | 肼解 重氮化 重排 2-氨基-4-氯吡啶 |
Study on Synthesis of 2-Amino-4-chloropyridine |
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| LIAO Jian-qiao.Study on Synthesis of 2-Amino-4-chloropyridine[J].Fine Chemical Intermediates,2010,40(6). |
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| Authors: | LIAO Jian-qiao |
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| Affiliation: | LIAO Jian-qiao(Zhejiang Jinming Pharmaceutical Co.; Ltd.; Sanmen 317100; China); |
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| Abstract: | 2-Amino-4-chloropyridine was synthesized in three steps in an overall yield of 68.5% using methyl 4-chloropicolinate as the starting material.The structure of the product was confirmed with 1H NMR and MS.The process is simple and feasible to large scale preparation. |
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| Keywords: | hydrazinolysis diazotization rearrangement 2-amino-4-chloropyridine |
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