Preparation of hollow hydroxyapatite microspheres |
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| Authors: | Qing Wang Wenhai Huang Deping Wang Brian W. Darvell Delbert E. Day Mohamed. N. Rahaman |
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| Affiliation: | (1) Institute of Bioengineering & Information Technology Materials, Tongji University, Shanghai, 200092, P.R. China;(2) Materials Research Center, University of MIssouri-Rolla, Rolla, MO 65409-1170, USA;(3) Dental Materials Science, Prince Philip Hospital, University of Hong Kong, Hong Kong, P.R. China;(4) Department of Matreials Science and Engineering, University of Missouri-Rolla, Rolla, MO 65409-0340, USA |
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| Abstract: | The preparation of hollow hydroxyapatite (HA) microspheres as potential drug-delivery vehicles was investigated. A lithium-calcium-borate (10Li2O-15CaO-75B2O3) (mol%) glass, made by fusing the components at 1100°C for 1 h, was ground to a powder and passed through a flame at ∼1400°C to spheroidize the particles. The resulting glass microspheres (106–125 μm in diameter) were reacted in 0.25 M K2HPO4 solution for 5 days at 37°C and pH 10–12, resulting in the formation of porous, hollow microspheres of a calcium phosphate (Ca-P) material with external diameters similar to those of the original glass particles. Heat treatment at 600°C for 4 h partially converted the Ca-P material to HA, as confirmed by X-ray diffraction, and also increased the strength of the hollow microspheres. |
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